Isoniazid, inh; pyrazinamide, pza; rifampin moderate a dose adjustment of triamcinolone may be necessary when administered concurrently with rifamycins, due to the potential for decreased exposure of triamcinolone.
Rifampin can increase the metabolism of isoniazid, inh into a hepatotoxic metabolite hydrazine .
Isoniazid and pyrazinamide are thought to have a greater potential for hepatotoxicity than rifampicin.
The reduction in mortality was similar in children assigned to isoniazid three times a week compared with every day test of heterogeneity p 0.
Isoniazid toxicity should be suspected in any patient who presents with refractory seizures and metabolic acidosis.
1 southeast asia isoniazid sales volume and growth rate 2012-2017 .